Biphasic augmentation of alpha-adrenergic contraction by plumbagin in rat systemic arteries

Biphasic augmentation of alpha-adrenergic contraction by plumbagin in rat systemic arteries

Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in pulmonary and coronary arteries where NADPH oxidase (NOX) inhibition was suggested as a mechanism. Here we investigate the effects of plumbagin on...

Alpha-2C Adrenergic Receptor Expression in Rat Caudal Tail Arteries

A positive and reversible relationship between adrenergic nerves and alpha-1A adrenoceptors in rat arteries.

We evaluated the relationship between the presence of adrenergic nerves and the presence of alpha-1 adrenoceptors (alpha-1 AR) in the arterial tree of the rat. The thoracic aorta and the carotid, mammary, renal and femoral arteries were isolated from 20-week-old male WKY rats, along with the superior mesenteric artery and small (first order) and resistance-sized (third order) side branches of t...

Characterization of Postsynaptic Alpha-Adrenergic Receptors by [H]-Dihydroergocryptine Binding in Muscular Arteries from the Rat Mesentery

Alpha-adrenergic receptors are likely to be Important determinants of the effects of catecbolamines on rascular resistance. To study the a-adrenergic receptor in muscular arteries of the type that determine vascular resistance, we characterized and qnantitated a-adrenergk receptors in a partknlate fraction of the highly reactive, richly Innervated arteries of the rat mesentery. With the ligand ...

Characterization of postsynaptic alpha-adrenergic receptors by [3H]-dihydroergocryptine binding in muscular arteries from the rat mesentery.

Alpha-adrenergic receptors are likely to be important determinants of the effects of catecholamines on vascular resistance. To study the alpha-adrenergic receptor in muscular arteries of the type that determine vascular resistance, we characterized and quantitated alpha-adrenergic receptors in a particulate fraction of the highly reactive, richly innervated arteries of the rat mesentery. With t...